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Anti-CD40 Antibody Fused to CD40 Ligand Is a Superagonist Platform for Adjuvant Intrinsic DC-Targeting Vaccines

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Retatrutide (also designated LY3437943) is a synthetic, investigational-grade peptide engineered as a unimolecular triple agonist targeting three key metabolic receptors simultaneously: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GcgR)

Rather known effects associated with GLP1R binding were detected at a dose of 0.2 mg SAR425899, including reduction of body weight, HbA1c, FPG and PPG but also the occurrence of gastrointestinal disorders