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This dual action of promoting fat breakdown while simultaneously reducing fat storage creates the net effect of adipose tissue reduction, all occurring at the peripheral tissue level without involvement of central appetite-regulating pathways in the hypothalamus

4.4 Potential impacts of OA ferroptosis on intestinal homeostasis In the collagen-induced arthritis mouse model, erastin promoted joint ferroptosis in a peptidylarginine deiminase 4 (PAD4)-dependent manner and exacerbated gut microbiota disturbance and altered gut-derived metabolites