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Without movement, its impact on fat metabolism is limited

Sulfonylurea drugs affect sulfonylurea receptor 1 (SUR 1), which leads to the closure of adenosine triphosphate (ATP)-dependent potassium channels, preventing potassium from leaving the cell and depolarizing the cell membrane, leading to an influx of calcium and triggering insulin release

Research also suggests MOTS-c contributes to improved insulin sensitivity and cellular resilience, making it a potential tool for both performance enhancement and healthy aging

Efficacy and safety of coadministered onceweekly cagrilintide 2.4 mg with onceweekly semaglutide 2.4 mg in type 2 diabetes: a multicentre, randomised, doubleblind, activecontrolled, phase 2 trial