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A study in the Journal of the American Medical Association supported that view, along with one in the journal Diabetes, Obesity and Metabolism that found that after stopping semaglutide for one year, people had regained two-thirds of the weight they had lost

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This facilitates an elevated thioredoxin-interacting protein (TXNIP) level, activating the NLRP3 inflammasome and Caspase-1