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Currently, there are a total of ten FDA-approved indications for hGH therapy [5]: Growth hormone deficiency in children and adults (GHD) Growth failure due to chronic renal insufficiency Muscle wasting due to AIDS Noonan syndrome Prader-Willi syndrome Short bowel syndrome (SBS) Short stature homeobox (SHOX)-containing gene deficiency Small-for-gestational-age infants Turner syndrome Recombinant hGH therapy can effectively and dose-dependently increase serum GH levels, hence its use in managing the symptoms of GHD in children and adults

A 52-week phase 2 trial on AMG133 in people with overweight and obesity is ongoing (NCT05669599)

Usually, being overweight or obese is caused by lifestyle choices, such as overeating or stress

Depending on the clinical picture, that typically includes: Relevant baseline bloodwork before starting IGF-1 dynamics where appropriate, so the response can be tracked rather than assumed Glucose and metabolic markers where relevant Follow-up adjustments based on results, tolerability, and goals A clear plan for duration and review rather than indefinite open-ended use This is also why CJC-1295 and Ipamorelin are often discussed alongside related options like Tesamorelin for visceral fat and metabolic goals