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The overarching cardioprotective effect is achieved through the restoration of mitochondrial integrity and function, as evidenced by the recovery of key components (e.g., SCO1, CCO, and SOD1) and upregulating the biogenesis regulator PGC-1 [51, 204]

Test of withdrawal symptoms in heroin withdrawal mice Sixteen male C57BL/6J mice were randomly assigned to either a heroin natural withdrawal group (H, n = 8) or a saline control group (S, n = 8)

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