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A systematic review and network meta-analysis found that GLP-1RAs, while reducing total weight and fat mass, led to a decrease in lean body mass (mean difference 0.86 kg), with the loss accounting for approximately 25% of the total weight loss [14]
Weight Loss: The Default Job The pivotal obesity trial enrolled about 1,960 non-diabetic adults with a mean weight of 105 kg, BMI of 38, average age of 46, and a cohort that was roughly three-quarters women
Berberine and garcinia show modest effects on glucose control and minor weight loss, but clinical evidence places them far below GLP-1 medications
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