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Furthermore, this paper discusses the technical challenges associated with using natural products in nasal drug delivery for disease treatment and suggests future directions to address these challenges (Figure 1)

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Additionally, it is now known that pro-inflammatory cytokines also hijack IGF-1 intracellular signalling by phosphorylating serine residues on insulin related substrate (IRS) molecules and hence impeding their binding to IGF-1R [124]

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