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Shah, R., Sabir, S., & Alhawaj, A

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It has been shown to enhance VEGF expression and endothelial proliferation and to stimulate eNOS phosphorylation via SrcCaveolin-1 signaling.60,61,64 Additional studies indicate that BPC 157 supports VEGFR2 internalization and VEGFR2AkteNOS activation, independent of shear stress or ligands, while also exerting context- specific control over angiogenesis, enhancing vascularization in ischemic muscle and tendon but suppressing pathological corneal neovascularization.46 Although direct associations with HIF-1 remain limited, its reported effects on VEGF and eNOS are consistent with modulation of hypoxia-regulated pathways.51,67 Our findings provide new insights into skeletal muscle I/R injury