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Because each of the major studies for SGLT2is, GLP1-RAs, and nsMRAs added these newer therapies to participants on the maximum label or tolerated dose of an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB), it is suggested that cardiorenal protective therapy begin with either an ACEi or an ARB, titrated to either the label maximum or the maximum tolerated dose (see Table 1 for list of currently approved ACEi and ARB in Canada and the maximally recommended dosing)

Gordons over 380 publications in quantum chemistry have had significant impact and won worldwide recognition, among real chemists as well as theorists, for his unique blend of systematic elucidations of important bonding and reaction mechanistic problems on the one hand and effective ab-initio method developments on the other hand

Both drugs share the same dual-agonist mechanism, differing primarily in their peptide chemistry, pharmacokinetic profiles, and clinical development strategies rather than fundamental pharmacology

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