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The 80% bioavailability, the extensive clinical trial data, the standardized dosing protocols, and the predictable outcomes make it the gold standard against which all alternatives are measured

CrossRef Multi-omics analysis elucidates the therapeutic mechanisms of the Quzhi formula in metabolic dysfunction-associated steatohepatitis targeting gut microbiota, lipid metabolism, and the role of its metabolite fraxin Jiao-Xiang Wu, Yue-Lan Wu, Mei-Fang Li, Nian Liu, Ying Liu, Yan-Ping Huang, Yuan Gan, Xiao-Yu Wang, Hai-Sheng Chai, Jin Xu, Qian Xi, Xi-Rong Guo, Hui-Ming Sheng, Ting-Ting Shen, Qin Zhang Frontiers in Pharmacology .2025;[Epub] CrossRef Implications of the Liver-Gut Axis in Liver Disease: From Mechanisms to Therapeutic Targets Mariana M

Lastly, HTA websites and databases for CADTH, PBAC, NICE, AWMSG, and SMC were searched

Both are effective times, provided the stomach is empty