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Therefore, in addition to L-carnitine for mitochondrial fatty acid transport, ALCAR provides acetyl-CoA that can be used for brain lipid synthesis, be oxidized in the citric acid cycle for energy production, or be incorporated into neurotransmitters such as acetylcholine [3639].* ALCAR has shown several benefits for brain health: it supported brain energy metabolism, brain mitochondrial function, neuronal membrane lipid/phospholipid metabolism, synaptic plasticity, and neuroprotective functions [4056]

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CoQ10 supplementation, when added to pregabalin, significantly reduced pain and mitochondrial oxidative stress in FM patients, with improved anxiety and brain activity profiles in a small RCT ( Oxygen-ozone (OO) therapy, an intervention that activates NRF2, increases SOD, catalase, and HO-1, while suppressing pro-inflammatory cytokines (IL-6, TNF-, IL-1) (33)