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[38] Therapeutic clinical trials Afamelanotide is being trialed by Clinuvel as a drug for photoprotection for five indications: Erythropoietic protoporphyria Polymorphous light eruption Phototoxicity associated with systemic photodynamic therapy Solar urticaria Actinic keratosis and squamous cell carcinoma skin cancer in patients who have received an organ tranplant [39] Clinuvel is also trialing the drug as a potential dermal repigmentation agent for: Erythropoietic protoporphyria Phase II trials of afamelanotide in erythropoietic protoporphyria (EPP) were completed in February 2007

Moderate portions are generally well tolerated

Medicare Data (2025): Once-weekly GLP-1 RAs (especially semaglutide) showed superior MACE reduction compared to SGLT2 inhibitors in Medicare beneficiaries with atherosclerotic cardiovascular disease (ASCVD)

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