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The FDA has required labeling updates to include warnings about persistent side effects, acknowledging that they occur in a subset of users beyond the treatment period

A 16-week observational study tracking this exact protocol found mean IGF-1 increases of 180220 ng/mL from baseline, with sustained elevation throughout the study period and no significant desensitisation at week 16

doi:10.2147/NSS.S344616

Curcumin prevents high-fat diet-induced hepatic steatosis in apoe/ mice by improving intestinal barrier function and reducing endotoxin and liver tlr4/nf-b inflammation