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Intensive Support Protocol For individuals with significant oxidative stress burdens, those recovering from illness or toxic exposures, or those pursuing more aggressive aesthetic goals, intensive protocols may involve 1000-2000mg administered 2-3 times weekly for defined periods (typically 8-12 weeks)

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or (2) for devices for which pass-through status will begin on or after January 1, 2020, as an alternative to the substantial clinical improvement criterion, the device is part of the FDA's Breakthrough Devices Program and has received FDA marketing authorization for the indication covered by the Breakthrough Device designation