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You may notice an increase in energy for daily activities and overall well-being

Last reviewed: June 22, 2026 Last updated: June 22, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Retatrutide , the triple agonist targeting GLP-1, GIP, and glucagon receptors, showed 24+ percent weight loss in phase 2 trials

Lifestyle Changes Still Matter Diet and Exercise Are Key Even with these powerful medications, healthy habits are still important: Eat a balanced diet with plenty of protein Stay active with regular exercise Drink enough water throughout the day Get adequate sleep each night Manage stress in healthy ways Long-Term Success Research shows these medications work best when combined with lifestyle changes