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The higher level of GSSG observed in the serum of many children with autism spectrum disorders [4648, 50, 85, 87, 91] is likely to truly reflect increased oxidative stress as there is no significant difference in GPx-1 activity in serum or platelets [63, 84] and GPx-1 is significantly lower in the erythrocytes of children with autistic disorder compared to controls

Topical retinoids are also effective at controlling the symptoms of melasma and brightening the skin by promoting skin cell turnover

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