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Vitamin B6 (pyridoxine) is a well-known, safe, well-researched, and effective remedy used for treating nausea and vomiting caused by motion sickness, pregnancy, and may also help with nausea when using GLP-1 medications such as tirzepatide

Initially, the dosage may start low and gradually increase to help your body adjust to the medication and minimize potential side effects

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Additionally, the gastrointestinal side effects of tirzepatide (nausea, vomiting, diarrhea) can cause volume depletion leading to low blood pressure, especially in patients taking diuretics or other antihypertensive medications