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Total triglyceride concentrations decreased, and HDL concentrations increased in both groups throughout the study up to week 3, but to a greater extent in the KD group than in the standard diet group

The focus is on achieving a healthy weight, recognizing that this is a critical aspect of overall well-being

Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]

The effect of GLP-1 receptor agonists on the exocrine pancreas and the risk of acute pancreatitis has remained a cause for concern