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This rapid clearance contrasts sharply with its prolonged biological effects, which is the basis of the Gene Expression Paradox

showed the relationships between eNAP-2 and several four-disulfide core antiproteases and also the relationships between eNAP-2 and equine cationic peptides exhibiting selective inhibitory activity against subtilisin and proteinase K (later denoted equinins), reported by Pellegrini et al

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