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It is thought that in PCOS, there is upregulation of epimerase the enzyme that converts myo-inositol to di-chiro-inositol

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Among the shared proteins between EVs and ExerVs, the top significantly upregulated proteins included integrin beta-1 (ITB1), calponin-2 (CNN2), fibronectin (FINC), myosin light polypeptide 6 (MYL6), alpha-enolase (ENOA), myosin regulatory light chain 12A (ML12A), and myosin regulatory light chain 12B (ML12B), thrombospondin-1 (TSP1), fibrinogen gamma chain (FIBG), integrin alpha-6 (ITA6), cofilin-1 (COF1), ras-related protein Rap-1b (RAP1B), vasodilator-stimulated phosphoprotein (VASP), (Fig