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Therefore, it remains unclear whether the reduction of steatosis observed in animal and human trials in response to treatment with GLP-1R agonists results from direct activation of hepatic GLP-1R or the indirect impact such as weight loss, increased insulin sensitivity, brain-liver signals such as brain leptin 51 , or other hormonal signals that these agonists might trigger 14

This is particularly important for medications with a narrow therapeutic index or those requiring rapid onset of action

This metabolic boost can aid weight management efforts when combined with a balanced diet and regular exercise

[Abstract]2021 Jun 18;4(8):e202000906