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Clinical trials further provide proof-of-concept: Vitamin B12 supplementation markedly improves symptom severity and anxiety in patients with FM, consistent with restoration of one-carbon flux and normalization of methylation-dependent pathways

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[DOI] [PubMed] [Google Scholar] 71.Yancy W.S., Olsen M.K., Guyton J.R., Bakst R.P., Westman E.C

Our results are in agreement with previous studies performed in bovines, where oocytes subjected to heat stress before 12 h of maturation 49 , or even in the short term at the early stage of maturation, resulted in increased Annexin-V binding and oocytes that underwent early apoptosis compared with those in the control group 51