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Furthermore, the addition of proline, a metabolite derived from glutamate, to an H 2 O 2 medium, followed by lens incubation, resulted in the prevention of opacity 28

In this study, glutamine flux was directed toward the generation of R-2-HG in IDH1/2 mutant cells, and the kinetics of R-2-HG formation were proportionally of the same order of magnitude as those of glutamate or -KG formation via glutaminolysis

Instead, it interacts with pathways that are already part of normal biology

Without maintenance, the improvements will gradually diminish over time as natural collagen loss continues, but much of the structural rebuilding persists