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The best way to get clear answers is to check your own benefits directly

In response to these challenges, the Muscle maintenance, Energy balance, Avoid side effects, Liquid intake (MEAL) plan has recently been proposed as a structured nutritional framework specifically designed to support patients undergoing GLP-1 RA therapy, such as semaglutide [88, 89]

Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction

Clinical trial data show that while fat mass accounts for the majority of weight loss, some lean mass reduction also occurs, which could potentially affect muscle function