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Bannister K, Kucharczyk M, Dickenson AH

======================================== What the Research Shows Several large studies identify associations between prenatal acetaminophen use and neurodevelopmental outcomes: A 2021 meta-analysis of 73,881 mother-child pairs found children prenatally exposed to acetaminophen were 19% more likely to have neurodevelopmental symptoms and 21% more likely to have ADHD symptoms

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Two mechanisms of reaction of these species with DNA and proteins are known: type I mechanism, involving one-electron transfer, and type II mechanism which can be divided into two subtypesmajor mechanism based on reaction with DNA via singlet oxygen, resulting in formation of 8-oxoguanine, and minor mechanism based on formation of a superoxide anion radical which undergoes disproportionation reaction, giving hydrogen peroxide and reactive oxygen species (IARC 2012)