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These changes can interact unpredictably, particularly in patients with a history of thyroid nodules, cancer, or uncontrolled diabetes

And recent research from experts at the Yale School of Medicine estimated that pharmaceutical companies could produce the drugs for as little as 75 cents per person for four monthly doses

The FDA in early 2026 highlighted enforcement actions targeting non-approved GLP-1 active ingredients in compounded drugs, which underscores the quality-control concern

Critics argue that the peptides have not undergone the large-scale clinical trials required for traditional FDA approval and warn that they could pose safety risks