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Figure 2 RA is classified into two major subtypes based on the presence or absence of anti-citrullinated protein antibodies (ACPAs), detectable in around 67% of patients and serving as a key diagnostic marker (49)

8 Nitric oxide (NO) normally activates soluble guanylate cyclase, to act as a neurotransmitter and blood pressure regulator

Sequencing libraries were prepared using the NEBNext UltraExpress RNA Library Prep Kit for Illumina (NEB, E3330) according to the manufacturer protocol and sequenced on DNBSEQ-G400, MGI (150 bp paired-end, minimum 100 mil reads per condition, 2 biological replicates)