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The same review flagged a persistent methodological gap: most evidence supporting ipamorelin's selectivity characterisation derives from acute-dose rodent studies and short-duration human pharmacokinetic assessments, leaving longer-term receptor desensitisation, tachyphylaxis, and off-target effects insufficiently characterised across multi-week exposure windows

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and step 3: stirring to dissolve and clarify the prepared solution, adding water for injection to full amount, and adjusting pH to 7.0 with 10% sodium hydroxide solution