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Dosing Protocols Retatrutide (existing protocol) Maintain your current titration: Standard: 0.25mg 0.5mg 1mg 2mg 3mg (weekly increases) Most users stabilize between 1-3mg weekly No need to adjust Reta dose when adding Tesamorelin or MOTS-C Tesamorelin Starting dose: 1mg daily Maintenance dose: 2mg daily Timing: Evening, before bed (aligns with natural GH pulsatility) Injection: SubQ, abdomen or thigh Cycle length: 12 weeks on, 4 weeks off (standard) MOTS-C Option A (daily): 500mcg-1mg daily, morning Option B (pulsed): 5mg 2-3x weekly Timing: Morning preferred (aligns with metabolic activity) Injection: SubQ, any site Cycle length: 8-12 weeks on, 4 weeks off (receptor sensitivity consideration) Daily Schedule Example This schedule keeps compounds separated and aligns with natural physiology (MOTS-C with daytime metabolic activity, Tesamorelin with nighttime GH pulsing)

Targeting the enteric nervous system to treat metabolic disorders

Appetite suppression becomes more consistent

These adaptations, sometimes called "metabolic adaptation" or "adaptive thermogenesis," make weight regain biologically likely without continued intervention