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Key Highlights AOD9604 activates lipolytic pathways through beta-3 adrenergic receptor upregulation and cAMP-PKA-HSL cascade activation in adipocytes The peptide inhibits acetyl-CoA carboxylase to suppress lipogenesis while promoting fatty acid oxidation in laboratory models Research confirms no IGF-1 stimulation or glucose metabolism disruption, distinguishing it from full-length growth hormone Cartilage studies show proteoglycan synthesis enhancement and improved tissue structure in osteoarthritis animal models What is AOD9604

Analyses were adjusted for age, sex, T2D duration, semaglutide dose, baseline endpoint level, index year (to account for reimbursement policy changes), and concomitant anti-diabetic treatment

The episode was published on September 30, 2023 1

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