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Clodi K, Kliche KO, Zhao S, Weidner D, Schenk T, Consoli U, Jiang S, Snell V, Andreeff M
In rabbit models, intra-articular injection of scAAV2 encoding interleukin-1 receptor antagonist (IL-1Ra) yielded sustained therapeutic protein expression in both inflamed and normal joints for at least two weeks, with minimal immune activation or joint pathology (178)
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Sublingual Absorption Sublingual, meaning literally under the tongue, refers to a method of administering substances orally in such a way that the substances are RAPIDLY and MORE EFFECTIVELY ABSORBED as compared to capsules or tablets via the digestive tract
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