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In particular, expression quantitative trait loci (eQTL) and protein quantitative trait loci (pQTL) analyses have emerged as powerful tools for identifying disease-associated genetic variants ( Building upon this, Mendelian randomization (MR), a causal inference method based on genetic variation, can effectively overcome confounding and reverse causation issues commonly seen in observational studies

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Notably, among the principal components evaluated for the histology score, H4R / mice had significantly lower cellular infiltration and decreased overall mucosal damage in both Ox- and DSS-induced colitis (Figure 2d, hj)