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458 CTLA-4 inhibitor ipilimumab has been approved by the FDA for the treatment of advanced metastatic melanoma, while it also exhibited modest antitumor activity observed in TNBC

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Key considerations for individuals with transcobalamin mutations include: Regular monitoring of vitamin B12 status Potential need for alternative forms of vitamin B12 supplementation Genetic counseling for family members Genetic Testing Recommendations Genetic testing is a good idea for those thinking about vitamin B12 supplements

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