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Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months

Furthermore, phase 3 clinical trials in T2D are ongoing with semaglutide administered orally (in a co-formulation with an absorption enhancer)

No matter what your situation, talking to a healthcare provider should be your first step in building a skincare routine that meets you where you are now