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Self-reported community sources describe headache, brain fog or mental fatigue, irritability, anxiety, nausea or GI upset, appetite and sleep changes, blood-pressure changes, and skin reactions when used transdermally in DMSO

By enhancing deep sleep stages and improving sleep efficiency, DSIP facilitates neuroendocrine processes that occur during sleep including hormonal balance, tissue repair, and stress regulation all key components of recovery

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FIGURE 3 Overall, most studies indicate that virtually all cells involved in skin repair (fibroblasts, keratinocytes, inflammatory cells, tissue stem cells, and vascular endothelial cells) express both ER and ER and are direct targets of E2 (Matsubara and Matsubara, 2012