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The mitochondrial electron transport and oxidative phosphorylation system

However, metformin can cross the placenta into the fetus, which has raised concerns about its safety and potential adverse effects

The results of several large randomized controlled trials indicated that maintaining blood glucose at near normal concentrations was the most important step in limiting the risk of diabetic neuropathy and lower extremity amputation (70-72)

Behav Brain Res 364:356365 Ferrari A, Somerville A, Baxter A, Norman R, Patten S, Vos T, Whiteford H (2012) Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature