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When exposed to increasing gradients of the stimulus, wt animals exhibited a pulsatile activity that adapted to the magnitude of the gradient's first derivative (Fig 6A)

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Autocrine GH for instance, is thought to be more oncogenic than pituitary GH, and the autocrine/paracrine IGF1 is the main determinant of postnatal body growth, including muscle and bone tissue development, confirming the conclusion that pituitary GH and circulating IGF1 are critical for body size and affect numerous body functions, for these body functions, local GH and IGF1 may be more relevant

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