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Liraglutide can enter specific brain regions associated with appetite regulation, electrophysiological measurements of mouse brain sections showed that GLP-1 directly stimulated promelanocortin (POMC)/cocaine and amphetamine regulated transcript (CART) neurons and indirectly inhibited neurotransmission of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in arcuate nucleus neurons through GABA-dependent signal transduction

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As expected it appears to be relationship between a compound's ability to bind HGF and its capacity to block dimerization and inhibit HGF-dependent activities (see Figures 25, 26, 27)