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This design is useful for generating preliminary evidence from real clinical practice, but it has limitations compared to a randomised controlled trial (RCT)

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found that SS-31 reduced Scr levels, increased creatinine clearance, reduced tubular necrosis and apoptosis, and preserved brush border structure in a group of experimental rats at both 30 and 45 min following bilateral renal blood flow blockade and that it showed a significant dose-dependent effect after 45 min of ischemia