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The Broad Institute, a genomic research center run by MIT and Harvard, maintains a database called the Connectivity Map that tracks how compounds shift gene expression across thousands of human cell lines

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The SAH hydrolase reaction is reversible, so methylation can remain blocked when homocysteine and especially adenosine are not adequately metabolized or removed

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These included an increase in intestinal lymphocyte numbers, reduced expression of microbial defense genes, and decreased cytokine production by intestinal type 2 innate lymphoid cells (ILC2)

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