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The evidence for carcinogenicity in these new studies is difficult to interpret at this time

However, the impact of metabolic adaptation on weight loss plateaus is controversial

The study authors concluded that micronutrient deficiencies during GLP-1 therapy are a common consequence rather than a rare adverse effect, and called for routine nutritional assessment in all long-term users

Plasma lipids are also considered important risk factors and the GLP-1RAs appear to reduce postprandial triglycerides (again by an unknown mechanism), and apolipoprotein (Apo) B48 may be reduced in parallel, suggesting that fat absorption is reduced