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Direct delivery of amino acids As mentioned earlier, the methionine dependence of tumors can be used for cancer treatment, but methionine is difficult to enter TME due to its highly aqueous solubility [268]

EXOs are a promising option for treating cancer because of their endogenous action, intrinsic targeting, and capacity to interact with the host defense system (Rodolakis et al., 2023)

In conclusion, the decision to explore glutathione for skin lightening should be carefully considered under a qualified dermatologists guidance

doi: 10.1007/s12020-018-1523-6 83 GolbertLde CristoAPFaccinCSFarenzenaMFolgieriniHGraudenzMSet al