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The use of GLP1R agonists for the treatment of type 2 diabetes in kidney transplant recipients

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In contrast and although LnCaP, a prostate cancer line, proved to be particularly sensitive to metformin and in a concentration range that was within that expected clinically and correlated with a high expression of mRNA for OCT3 and low expression of MATE2 for the other cell lines, very high concentrations, up to 10mM, of metformin were required to see significant inhibition, and a strong significant correlation between inhibition of proliferation and MATE2 expression was not seen (254)

The additional GIP receptor engagement is thought to amplify satiety signaling in the hypothalamus and augment insulin secretion in a glucose-dependent fashion, without proportionally increasing nausea at therapeutic doses