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Both the National Institutes of Health (NIH) and the Institute of Medicine have not established an upper limit for B12 intake, even when doses exceed the daily recommended amounts by thousands of micrograms (source: National Institutes of Health)

On the other hand, too much B12 in your body can also give you vitiligo, mouth ulcers, eczema, and acne

Depending on your protocol and comfort level, some patients may be trained to self-administer certain vitamin injections at home (such as B12)

The measurement of TCN2-Cbl provides a more accurate reflection of the vitamin B12 status, particularly in the context of neurological disorders, as it specifically quantifies the fraction of Cbl bound to TCII and available for cellular uptake and metabolism [133]