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In obese individuals there is a reduced level of PP secretion in response to food intake, whereas, in anorexia nervosa there is increased PP release following consumption of food

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Shared epigenetic mechanisms in depression-drug addiction comorbidity To better integrate these findings, we introduce a unifying three-axis framework, stress-response regulation, reward-circuit remodeling, and synaptic plasticity, which provides a coherent structure for understanding how epigenetic alterations converge across depression, drug addiction, and drug addiction-induced depression