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Research suggests that glutathione may affect pigmentation through several possible mechanisms: Reducing oxidative stress that can influence pigment formation Affecting tyrosinase activity involved in melanin production Supporting a shift in melanin production pathways This does not mean glutathione removes natural skin colour or permanently changes genetics

Currently, there are several strategies for overcoming chemoresistance in cancer, including discontinuous dosing, modifying drug concentrations, combination therapy, and the use of natural products ( In this review, we aim to understand the mechanisms of chemotherapy resistance in GC and to explore the potential of TCM and its active components as chemotherapy sensitizers in reversing chemotherapy resistance and improving curative effect in GC

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