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Chronic kidney disease, congestive heart failure, G6PD enzyme deficiency, and active pregnancy each require physician medical clearance before any elective IV therapy is administered contraindications confirmed by the 2025 Cureus peer-reviewed review and the CDC heat stress guidance

Also promotes sleep, reduces anxiety, and has a calming effect on the nervous system

Proper storage maintains glutathione potency and prevents premature melting

This disruption is thought to affect the normal processes of synaptic plasticity, cognitive development, and motor coordination, contributing to the characteristic symptoms of the syndrome