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As shown in Figure 3 , pretreatment with PKI (a specific PKA inhibitor) had no effects on exendin-4-mediated inhibition of MG-induced intracellular and mitochondrial ROS production ( Figures 3A, B , respectively) and MG-induced MMP reduction ( Figure 3C )

The data uses population-average parameters from published clinical trials

BAC water amount, strength of peptide vial and syringe size all affect the final conversion