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Thus, genetic variants are expected to have only minor effects on the overall risk of disease, and various hereditary factors combined with environmental factors such as stress are likely more essential for the development of MDD

Specifically, DJ-1 preserves the activity of S-adenosylhomocysteine hydrolase (SAHH), the key enzyme that hydrolyzes S-adenosylhomocysteine (SAH) to homocysteine within this metabolic cascade